Comparison of subjective cognitive decline and polygenic risk score in the prediction of all-cause dementia, Alzheimer’s disease and vascular dementia
Unlike PRS, information on SCD can be assessed more efficiently, and thus, the model including SCD can be more easily transferred to the clinical setting. Nevertheless, the two variables seem negligible if APOE ε4 carrier status is available.
Authors
- Ben Schöttker (ORCID: https://orcid.org/0000-0002-1217-4521)
- Kira Trares (ORCID: https://orcid.org/0000-0002-1775-3231)
- Laura Perna
- Joshua Stevenson‐Hoare (ORCID: https://orcid.org/0000-0002-6823-5469)
- Bernd Holleczek (ORCID: https://orcid.org/0000-0001-8759-4371)
- Hannah Stocker (ORCID: https://orcid.org/0000-0001-5281-2455)
- Hermann Brenner (ORCID: https://orcid.org/0000-0002-6129-1572)
- Konrad Beyreuther
Institutions
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- Krebsregister Saarland (DE)
- Max Planck Institute of Psychiatry (DE)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1186/s13195-024-01559-9
- Citations
- 6
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.48
Funders
- Bundesministerium für Bildung und Forschung