Therapeutic potential of a novel pyrazolyl-pyridine derivative in the treatment of experimental colitis
<b>Aim:</b> Investigating a novel compound, DMPNP, for treating colitis in mice, a key issue in inflammatory bowel diseases (IBD).<b>Methods:</b> Mice with induced colitis received DMPNP (50, 100, 150 mg/kg) or sulfasalazine (SUL), evaluated via tissue assessment, Disease Activity Index (DAI), myeloperoxidase (MPO), nitric oxide (NO) levels and cytokine analysis.<b>Results:</b> DMPNP significantly reduced colitis symptoms, inflammation and oxidative stress at higher doses, with marked improvements in DAI, MPO, NO and cytokines, comparable to SUL results.<b>Conclusion:</b> DMPNP shows potent anti-inflammatory and immunomodulatory properties, indicating potential as an IBD therapeutic. Further clinical trials are suggested to validate these outcomes.
Authors
- Yousra Bseiso (ORCID: https://orcid.org/0000-0002-4346-5049)
- Abdelrahim M. Alqudah (ORCID: https://orcid.org/0000-0003-3721-8225)
- Kayed A. Abu Safieh (ORCID: https://orcid.org/0000-0001-9810-1982)
- Mohammed Wedyan (ORCID: https://orcid.org/0000-0002-8693-5506)
- Badriyah S. Alotaibi (ORCID: https://orcid.org/0000-0002-4066-5694)
- Esam Y. Qnais (ORCID: https://orcid.org/0000-0002-6203-4527)
- Omar Gammoh (ORCID: https://orcid.org/0000-0001-8801-2652)
- Mohammad Alemleh (ORCID: https://orcid.org/0000-0002-1618-2289)
- Mohammed Alqudah
Institutions
- Princess Nourah bint Abdulrahman University (SA)
- Hashemite University (JO)
- Arabian Gulf University (BH)
- Yarmouk University (JO)
Publication Details
- Journal
- Future Medicinal Chemistry
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1080/17568919.2024.2385298
- Citations
- 1
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.55
Funders
- Princess Nourah Bint Abdulrahman University
- Deanship of Scientific Research, Princess Nourah Bint Abdulrahman University