Thermodynamically Templated Macrocyclizations: Enhancing the Synthesis of Prism[5]arenes with Tailor-Made Guests
The macrocyclization of 2,6-dialkoxynaphthalene monomers to prism[5]arenes is thermodynamically templated by DABCO cations. In this study, we demonstrate that a greater template affinity for prism[5]arene improves the macrocyclization yield. By using novel templating cations, the yield of alkoxy-prism[5]arenes increases significantly compared with those of previously reported procedures, while the purification process becomes easier and faster.
Authors
- Carmine Gaeta (ORCID: https://orcid.org/0000-0002-2160-8977)
- Rocco Del Regno (ORCID: https://orcid.org/0000-0002-6470-511X)
- Margherita De Rosa (ORCID: https://orcid.org/0000-0001-7451-5523)
- Carmen Talotta (ORCID: https://orcid.org/0000-0002-2142-6305)
- Paolo Della Sala (ORCID: https://orcid.org/0000-0002-6379-0332)
- Giuseppa Campanile
- Claudia Argenio
- Anna Palmieri
Institutions
- University of Salerno (IT)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1021/acs.orglett.4c02590
- Citations
- 6
- Primary Topic
- Supramolecular Chemistry and Complexes
- Type
- article
- Field-Weighted Citation Impact
- 1.50
Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca