Bacterial sepsis causes more dramatic pathogenetic changes in the Th1 pathway than does viral (COVID-19) sepsis: a prospective observational study of whole blood transcriptomes
Our study illuminated distinct molecular variances between bacterial sepsis and viral (COVID-19) sepsis. Bacterial sepsis patients had a greater number of upregulated and downregulated genes and pathways compared to viral (COVID-19) sepsis patients. Especially, bacterial sepsis caused more dramatic pathogenetic changes in the Th1 pathway than did viral (COVID-19) sepsis.
Authors
- Daisuke Okuzaki (ORCID: https://orcid.org/0000-0002-4552-783X)
- Shinya Onishi (ORCID: https://orcid.org/0000-0003-0126-2320)
- Jumpei Yoshimura (ORCID: https://orcid.org/0000-0002-4092-8140)
- Jun Oda (ORCID: https://orcid.org/0000-0002-8254-3716)
- Yumi Mitsuyama (ORCID: https://orcid.org/0000-0002-6272-6910)
- Hiroshi Ogura (ORCID: https://orcid.org/0000-0002-5013-2445)
- Hiroshi Itô (ORCID: https://orcid.org/0000-0003-1029-5730)
- Arisa Muratsu (ORCID: https://orcid.org/0000-0002-7035-7684)
- Hisatake Matsumoto (ORCID: https://orcid.org/0000-0001-5771-570X)
- Yuki Togami
- Sayaka Oda
Institutions
- Osaka City University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Virology Journal
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1186/s12985-024-02451-6
- Citations
- 10
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.87
Funders
- Japan Agency for Medical Research and Development