miR-450a-2-3p targets ERK(1/2) to ameliorate ISO-induced cardiac fibrosis in mice
Our study reveals the mechanistic connection between ISO-induced myocardial fibrosis and the miR-450a-2-3p/ERK(1/2) signaling pathway, highlighting its role in the development of cardiac fibrosis. Modulating miR-450a-2-3p expression and inhibiting ERK(1/2) activation are promising approaches for therapeutic intervention in patients with AF.
Authors
- Langsha Liu
- Fanyan Luo (ORCID: https://orcid.org/0000-0002-1195-4585)
Institutions
- Central South University (CN)
- Third Xiangya Hospital (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Genes & Nutrition
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1186/s12263-024-00753-6
- Citations
- 3
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 1.21
Funders
- National Natural Science Foundation of China