Forty years of human G‐<scp>CSF</scp>: A short history in time

Human G-CSF was identified in 1984 at Memorial Sloan-Kettering Cancer Centre, New York. Based on these findings, recombinant G-CSF was developed by Amgen, Thousand Oaks. In 1987, clinical trials began using recombinant G-CSF in cancer patients following chemotherapy to reduce the duration of neutropenia and in patients with congenital neutropenia (CN) to increase the number of neutrophils. It has changed the quality of life for many cancer patients and saved the lives of many patients with (CN).

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Publication Details

Journal
British Journal of Haematology
Published
2024-08-19
DOI
https://doi.org/10.1111/bjh.19713
Citations
3
Primary Topic
Blood disorders and treatments
Type
article
Field-Weighted Citation Impact
1.65
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article

Forty years of human G‐CSF: A short history in time

Karl Welte
3 citations
British Journal of Haematology
Blood disorders and treatments
1.65
article

Forty years of human G‐CSF: A short history in time

Karl Welte
article en
3 citations

Abstract

Human G-CSF was identified in 1984 at Memorial Sloan-Kettering Cancer Centre, New York. Based on these findings, recombinant G-CSF was developed by Amgen, Thousand Oaks. In 1987, clinical trials began using recombinant G-CSF in cancer patients following chemotherapy to reduce the duration of neutropenia and in patients with congenital neutropenia (CN) to increase the number of neutrophils. It has changed the quality of life for many cancer patients and saved the lives of many patients with (CN).

British Journal of HaematologyVol. 205(4)
University Children's Hospital Tübingen (DE)
Openalex Percentile: Top 15%
Blood disorders and treatments
1.65
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