Epidermal proteomics demonstrates Elafin as a psoriasis‐specific biomarker and highlights increased anti‐inflammatory activity around psoriatic plaques
Overall, these findings highlight the potential of epidermal non-invasive sampling and proteomic analysis to increase our diagnostic and pathophysiologic understanding of skin diseases. Moreover, the identification of molecular differences in healthy-looking skin between patients and healthy controls highlights potential disease susceptibility markers and proteins involved in the initial stages of disease.
Authors
- Anna Berekméri (ORCID: https://orcid.org/0000-0001-5894-8812)
- Daniela Kramer (ORCID: https://orcid.org/0000-0002-3451-6182)
- Isabel Hyde
- Gregor Ojak (ORCID: https://orcid.org/0009-0000-1675-186X)
- Miriam Wittmann (ORCID: https://orcid.org/0000-0003-2328-4926)
- Martin Stacey
- Tom Macleod (ORCID: https://orcid.org/0000-0002-7903-2990)
- Caroline Mann (ORCID: https://orcid.org/0000-0001-7044-2216)
Institutions
- University of Leeds (GB)
- Johannes Gutenberg University Mainz (DE)
- National Institute for Health and Care Research (GB)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- NIHR Leeds Musculoskeletal Biomedical Research Unit (GB)
Publication Details
- Journal
- Journal of the European Academy of Dermatology and Venereology
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1111/jdv.20289
- Citations
- 5
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.67
Funders
- Psoriasis Association