Catalytic Asymmetric Reductive Amination for Axially Chiral Aryl Aldehydes via Desymmetrization/Kinetic Resolution Cascade
Herein we present an efficient chiral phosphoric-acid-catalyzed atropoenantioselective asymmetric reductive amination of biaryl dialdehydes. The process involves desymmetrization and the following kinetic resolution, with a wide range of axially chiral aryl aldehydes obtained with high optical purities.
Authors
- Dao‐Juan Cheng (ORCID: https://orcid.org/0000-0001-7834-7563)
- Wenli Chen (ORCID: https://orcid.org/0000-0002-4768-3844)
- You‐Dong Shao (ORCID: https://orcid.org/0000-0002-6597-9526)
- Shuhui Zhang (ORCID: https://orcid.org/0000-0003-4569-9698)
- Rui‐Ping Song
- Xinyue Li (ORCID: https://orcid.org/0000-0002-2630-899X)
- Yi Wang (ORCID: https://orcid.org/0009-0001-4960-8610)
- Yu Tian (ORCID: https://orcid.org/0000-0002-5703-7336)
Institutions
- Anhui University of Traditional Chinese Medicine (CN)
- Heze University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1021/acs.orglett.4c02540
- Citations
- 8
- Primary Topic
- Axial and Atropisomeric Chirality Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 2.00
Funders
- National Natural Science Foundation of China
- Anhui University of Chinese Medicine
- Heze University