Palladium-Catalyzed Regio- and Diastereoselective Hydro(hetero)arylation for Rapid Construction of Quaternary Center Containing Cyclobutanes
Herein we report a Pd-catalyzed regio- and diastereoselective hydro(hetero)arylation of inactivated alkylidenecyclobutanes. This protocol provides a rapid and atom-economical route to access 3-cyclobutyl (hetero)arenes with good functionalities toleration. With the assistance of the directing group, nucleophilic attack happened on the bulkier γ-position to form the quaternary carbon center. Furthermore, the selected products exhibited antitumor bioactivities.
Authors
- Jia Zheng (ORCID: https://orcid.org/0000-0003-2700-6413)
- Mandalaparthi Phanindrudu (ORCID: https://orcid.org/0000-0003-1529-6855)
- Shuaikang Li
- Hui Luo (ORCID: https://orcid.org/0000-0001-6121-1715)
- Yi Qi (ORCID: https://orcid.org/0000-0003-4986-2245)
- Furong Tao (ORCID: https://orcid.org/0000-0002-5255-9733)
- Haifei Yang
Institutions
- Guangdong Medical College (CN)
- Marine Biomedical Research Institute of Qingdao (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1021/acs.orglett.4c02645
- Citations
- 2
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.50
Funders
- Basic and Applied Basic Research Foundation of Guangdong Province