Electrochemical Trifluoromethylthiolation/Cyclization of <i>N</i>-Arylacrylamides with AgSCF<sub>3</sub>: Access to SCF<sub>3</sub>-Containing Oxindoles
An environmentally friendly electrochemical strategy for the synthesis of SCF<sub>3</sub>-containing oxindoles was developed. This electrochemical transformation was accomplished through a cascade trifluoromethylthiolation/cyclization of <i>N</i>-acrylamides with AgSCF<sub>3</sub>, obviating the requirement for external oxidants. A variety of functional groups were well tolerated in this transformation.
Authors
- Wenbo Chen (ORCID: https://orcid.org/0000-0002-4517-2952)
- Siqi Wang (ORCID: https://orcid.org/0000-0002-1502-4238)
- Yu Zhou (ORCID: https://orcid.org/0000-0003-4742-3150)
- Yu Wang (ORCID: https://orcid.org/0000-0003-3742-669X)
- Sheng Wang (ORCID: https://orcid.org/0009-0006-8839-3006)
- Ye Wang (ORCID: https://orcid.org/0000-0002-5383-2690)
Institutions
- Shanghai University of Electric Power (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1021/acs.joc.4c00433
- Citations
- 3
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.62
Funders
- Natural Science Foundation of Shanghai
- Science and Technology Commission of Shanghai Municipality