Intravenous Lidocaine for Refractory Pain in Patients With Pancreatic Ductal Adenocarcinoma and Chronic Pancreatitis: A Multicenter Prospective Nonrandomized Pilot Study
Intravenous lidocaine in patients with painful PDAC and CP did not show an overall clinically relevant reduction of pain. However, this pilot study shows that the treatment is feasible in this patient group and had a positive effect in a third of patients which lasted up to a month with only minor side effects. To prove or exclude the efficacy of intravenous lidocaine, the study should be performed in a study with a greater sample size and less heterogeneous patient group.
Authors
- Rogier P. Voermans (ORCID: https://orcid.org/0000-0002-9969-019X)
- Casper H.J. van Eijck (ORCID: https://orcid.org/0000-0002-9511-2157)
- Werner ten Hoope (ORCID: https://orcid.org/0000-0001-7050-8019)
- Marc G. Besselink (ORCID: https://orcid.org/0000-0003-2650-9350)
- Stefan A.W. Bouwense (ORCID: https://orcid.org/0000-0002-7600-9429)
- Henk J. van Kranen (ORCID: https://orcid.org/0000-0001-7777-3245)
- Jan Willem Kallewaard (ORCID: https://orcid.org/0000-0002-7681-1796)
- Marja A. Boermeester (ORCID: https://orcid.org/0000-0003-3890-8105)
- Monique A. H. Steegers (ORCID: https://orcid.org/0000-0003-0812-5089)
- Judith de Vos‐Geelen (ORCID: https://orcid.org/0000-0003-2578-1766)
- Charlotte L. van Veldhuisen (ORCID: https://orcid.org/0000-0002-4230-3478)
- Olivier R. Busch (ORCID: https://orcid.org/0000-0001-9605-6831)
- Marco J. Bruno (ORCID: https://orcid.org/0000-0001-9181-5499)
- Bert A. Bonsing (ORCID: https://orcid.org/0000-0003-4513-5737)
- Jan H.M. Van Zundert
- Niels C.J. Schellekens
- Markus W. Hollmann (ORCID: https://orcid.org/0000-0002-8421-6911)
- Simone Augustinus (ORCID: https://orcid.org/0000-0002-0625-4349)
- Matthanja Bieze (ORCID: https://orcid.org/0009-0002-7430-1984)
- Marieke Niesters (ORCID: https://orcid.org/0009-0002-2822-7509)
- Johanna W. Wilmink (ORCID: https://orcid.org/0000-0002-1677-1278)
Institutions
- University of Toronto (CA)
- Leiden University Medical Center (NL)
- Maastricht University Medical Centre (NL)
- Toronto General Hospital (CA)
- Erasmus MC (NL)
- Maastricht University (NL)
- Ziekenhuis Oost-Limburg (BE)
- Metropolitan University (BD)
- Amsterdam University Medical Centers (NL)
- Rijnstate Hospital (NL)
- Cancer Center Amsterdam (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Clinical and Translational Gastroenterology
- Published
- 2024-08-19
- DOI
- https://doi.org/10.14309/ctg.0000000000000760
- Citations
- 4
- Primary Topic
- Pain Management and Opioid Use
- Type
- article
- Field-Weighted Citation Impact
- 2.57