Unmasking of molecular players: proteomic profiling of vitreous humor in pathologic myopia
Our study provides novel insights into the molecular mechanisms of PM. The differentially expressed proteins EEF1A1, TUBA1A, XYLT1, VCAN, and SPOCK2 may play crucial roles in chorioretinal cell apoptosis, scleral extracellular matrix (ECM) synthesis, and scleral remodeling in PM. These proteins represent potential new targets for therapeutic intervention in PM, highlighting the importance of further investigations to elucidate their functions and underlying mechanisms in disease pathogenesis.
Authors
- Lvzhen Huang (ORCID: https://orcid.org/0000-0002-2366-5350)
- Huijun Qi
- Kai You Wang (ORCID: https://orcid.org/0000-0002-6170-4744)
- Li Zhu (ORCID: https://orcid.org/0000-0001-5249-6536)
- Chi Ren (ORCID: https://orcid.org/0009-0009-8822-7552)
- Qiong Xu
- Mingwei Zhao (ORCID: https://orcid.org/0000-0002-6120-5654)
- Wenzhen Yu
- Yue Wen
Institutions
- Peking University (CN)
- Peking University People's Hospital (CN)
- He Eye Hospital (CN)
- Illinois College of Optometry (US)
Publication Details
- Journal
- BMC Ophthalmology
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1186/s12886-024-03584-6
- Citations
- 4
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.15
Funders
- National Natural Science Foundation of China
- Peking University
- Peking University People's Hospital
- NIH Clinical Center