A spike-based mRNA vaccine that induces durable and broad protection against porcine deltacoronavirus in piglets

As an emerging porcine enteropathogenic coronavirus, porcine deltacoronavirus (PDCoV) has the potential for cross-species transmission, attracting extensive attention. Messenger RNA (mRNA) vaccines are a promising option for combating emerging and re-emerging infectious diseases, as evidenced by the demonstrated efficacy of the COVID-19 mRNA vaccine. Here, we first demonstrated that PDCoV-S mRNA-lipid nanoparticle (LNP) vaccines could induce potent humoral and cellular immune responses in mice. An evaluation of passive immune protection of S mRNA vaccines in suckling piglets confirmed that the protective effect of mRNA vaccine was better than that of inactivated vaccine. This study suggests that the PDCoV-S mRNA-LNP vaccine may serve as a potential and novel vaccine candidate for combating PDCoV infection.

Authors

Institutions

Publication Details

Journal
Journal of Virology
Published
2024-08-19
DOI
https://doi.org/10.1128/jvi.00535-24
Citations
27
Primary Topic
Animal Virus Infections Studies
Type
article
Field-Weighted Citation Impact
9.20

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

A spike-based mRNA vaccine that induces durable and broad protection against porcine deltacoronavirus in piglets

Jizong Li, Tianyi Zhong, Liyuan Fan, Li Xiao et al.
27 citations
Journal of Virology
Animal Virus Infections Studies
9.20
article

A spike-based mRNA vaccine that induces durable and broad protection against porcine deltacoronavirus in piglets

Jizong Li, Tianyi Zhong, Liyuan Fan, Li Xiao, Baochao Fan, Lixiang Zhao, Bin Li, Xing Zhu, Wei Wang, Rongli Guo, Zhuoqi Chen, Zhaoming He, Jianhao Jiang, Hongpeng Hu
article en
27 citations

Abstract

As an emerging porcine enteropathogenic coronavirus, porcine deltacoronavirus (PDCoV) has the potential for cross-species transmission, attracting extensive attention. Messenger RNA (mRNA) vaccines are a promising option for combating emerging and re-emerging infectious diseases, as evidenced by the demonstrated efficacy of the COVID-19 mRNA vaccine. Here, we first demonstrated that PDCoV-S mRNA-lipid nanoparticle (LNP) vaccines could induce potent humoral and cellular immune responses in mice. An evaluation of passive immune protection of S mRNA vaccines in suckling piglets confirmed that the protective effect of mRNA vaccine was better than that of inactivated vaccine. This study suggests that the PDCoV-S mRNA-LNP vaccine may serve as a potential and novel vaccine candidate for combating PDCoV infection.

Journal of VirologyVol. 98(9)
Jiangsu University (CN), Nanjing Agricultural University (CN), Guizhou University (CN), Jiangsu Academy of Agricultural Sciences (CN), Jilian Technology Group (China) (CN), Jiangsu Food and Pharmaceutical Science College (CN), Ministry of Agriculture (CA), Yangzhou University (CN), Taizhou University (CN)
National Natural Science Foundation of China, China Postdoctoral Science Foundation, Government of Jiangsu Province, Zhejiang Sci-Tech University, National Key Research and Development Program of China
Openalex Percentile: Top 1%
Animal Virus Infections Studies
9.20
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.