The CpxAR signaling system confers a fitness advantage for flea gut colonization by the plague bacillus
The bacterium <i>Yersinia pestis</i> is the agent of flea-borne plague. Our knowledge of the mechanisms used by the plague bacillus to infect the flea vector is limited. The up-regulation of the envelope stress response under the control of the Cpx signaling pathway was previously shown in a transcriptomic study. Here, our <i>in vivo</i> and <i>in vitro</i> approaches suggest a model in which <i>Y. pestis</i> uses the CpxAR phosphorelay system to sense and respond to the copper present in the flea gut, thereby optimizing the flea gut colonization. In other words, the system is essential for bacterial fitness in the flea.
Authors
- Gabriel Billon (ORCID: https://orcid.org/0000-0002-4693-5106)
- Cécile Lecœur (ORCID: https://orcid.org/0000-0003-0075-6417)
- François Pierre (ORCID: https://orcid.org/0000-0002-7067-062X)
- Véronique Alaimo (ORCID: https://orcid.org/0000-0002-9503-8655)
- Amélie Dewitte
- Florent Sebbane (ORCID: https://orcid.org/0000-0003-3811-9691)
- Sébastien Bontemps-Gallo (ORCID: https://orcid.org/0000-0002-1834-5416)
- Brandon Robin (ORCID: https://orcid.org/0000-0002-5851-3744)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université de Lille (FR)
- Institut Pasteur de Lille (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Center for Infection and Immunity of Lille (FR)
- Laboratoire de Spectroscopie pour les Interactions, la Réactivité et l'Environnement (FR)
Publication Details
- Journal
- Journal of Bacteriology
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1128/jb.00173-24
- Citations
- 4
- Primary Topic
- Yersinia bacterium, plague, ectoparasites research
- Type
- article
- Field-Weighted Citation Impact
- 2.20
Funders
- Université de Lille
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Centre National de la Recherche Scientifique
- Institut Chevreul
- European Regional Development Fund