The role of <scp>DPYD</scp> and the effects of <scp>DPYD</scp> suppressor luteolin combined with 5‐<scp>FU</scp> in pancreatic cancer
We have elucidated that DPYD expression contributes to proliferation, invasiveness, and 5-FU resistance, in PDACs. The combination therapy of Lut and 5-FU holds the potential for enhanced efficacy against PDACs.
Authors
- Akihisa Kato (ORCID: https://orcid.org/0000-0002-7733-7854)
- Satoru Takahashi (ORCID: https://orcid.org/0000-0002-8139-8158)
- Masayuki Komura (ORCID: https://orcid.org/0009-0005-0000-5009)
- Hideaki Ijichi (ORCID: https://orcid.org/0000-0002-2379-7986)
- Aya Naiki‐Ito (ORCID: https://orcid.org/0000-0003-0828-2033)
- Yuko Nagayasu
- Kuang Xiaochen
- Hiroyuki Kato (ORCID: https://orcid.org/0000-0002-5888-6217)
- Shingo Inaguma (ORCID: https://orcid.org/0000-0001-8585-8900)
- Yoichi Matsuo (ORCID: https://orcid.org/0000-0001-9654-6080)
- Makoto Sano (ORCID: https://orcid.org/0000-0001-6718-2353)
- Motonori Sato
Institutions
- Nihon University (JP)
- Nagoya City University (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1002/cam4.70124
- Citations
- 9
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 2.54
Funders
- Nagoya City University