Resistin and In-Hospital Mortality in Patients with Acute Ischemic Stroke: A Prospective Study

<b>Background/Objectives</b>: Understanding the prognostic factors of acute ischemic stroke (AIS) is essential for improving patient outcomes. The aim of this study was to establish the predictive role of plasmatic resistin and leptin on short-term mortality in adult patients with a first episode of AIS. <b>Methods</b>: This study enrolled 277 patients who were consecutively hospitalized for AIS. Demographic data, cardiovascular risk, comorbidities, and laboratory tests were collected. Death was noted if it occurred during hospitalization. <b>Results</b>: Death was recorded in 33 (11.9%) patients. Conducting multivariate analysis, the following variables were independent variables associated with in-hospital mortality: a resistin value of >11 ng/mL (OR 10.81 (95%CI 2.31;50.57), <i>p</i> = 0.002), a lesion volume of >18.8 mL (OR 4.87 (95%CI 1.87;12.67), <i>p</i> = 0.001), a NIHSS score of >7 (OR 5.88 (95%CI 2.01;17.16), <i>p</i> = 0.001), and the presence of IHD (OR 4.33 (95%CI 1.66;11.27), <i>p</i> = 0.003). This study has some limitations: single-center design (which may affect the generalizability of the results) and the potential impact of the COVID-19 pandemic on patient outcomes. <b>Conclusions</b>: This study demonstrated that resistin is a significant predictor of in-hospital mortality in AIS patients. Other established factors, such as a high NIHSS score, large lesion volume, and the presence of IHD, were reaffirmed as important predictors.