Effect of Menopausal Hormone Therapy on Cellular Immunity Parameters and Cytokine Profile
We have demonstrated for the first time that oral therapy, in contrast to transdermal therapy, has a more pronounced effect on specific immune subpopulations of blood cells in menopausal women. This effect is likely to be responsible for its anti-aging properties in the context of immune aging as well as its protective effects in infectious diseases. Perhaps testing blood immune parameters or assessing immune status before prescribing MHT could become a routine step in clinical practice before choosing a patient management strategy.
Authors
- Timur Fatkhudinov (ORCID: https://orcid.org/0000-0002-6498-5764)
- Andrey Elchaninov (ORCID: https://orcid.org/0000-0002-2392-4439)
- Polina Vishnyakova (ORCID: https://orcid.org/0000-0001-8650-8240)
- В. В. Вторушина (ORCID: https://orcid.org/0000-0002-8406-3206)
- Г. Т. Сухих (ORCID: https://orcid.org/0000-0002-7712-1260)
- Krechetova L.V. Krechetova (ORCID: https://orcid.org/0000-0001-5023-3476)
- Anna S. Pavlova (ORCID: https://orcid.org/0000-0002-4939-1028)
- В. В. Киселева (ORCID: https://orcid.org/0000-0002-3001-4820)
- S. V. Yureneva (ORCID: https://orcid.org/0000-0003-2864-066X)
- O. V. Yakushevskaya (ORCID: https://orcid.org/0000-0002-7430-1207)
- T. Yu. Ivanets (ORCID: https://orcid.org/0000-0002-7990-0276)
- Marina Averyanova
- N. V. Mikhanoshina (ORCID: https://orcid.org/0000-0002-2868-0867)
- Marina Iskusnykh
Institutions
- Peoples' Friendship University of Russia (RU)
- National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation (RU)
- Research Institute of Human Morphology (RU)
Publication Details
- Journal
- Biomedicines
- Published
- 2024-08-19
- DOI
- https://doi.org/10.3390/biomedicines12081892
- Citations
- 5
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 2.33