Multi‐Tissue Integrated Tissue‐Engineered Trachea Regeneration Based on 3D Printed Bioelastomer Scaffolds
Functional segmental trachea reconstruction is a critical concern in thoracic surgery, and tissue-engineered trachea (TET) holds promise as a potential solution. However, current TET falls short in fully restoring physiological function due to the lack of the intricate multi-tissue structure found in natural trachea. In this research, a multi-tissue integrated tissue-engineered trachea (MI-TET) is successfully developed by orderly assembling various cells (chondrocytes, fibroblasts and epithelial cells) on 3D-printed PGS bioelastomer scaffolds. The MI-TET closely resembles the complex structures of natural trachea and achieves the integrated regeneration of four essential tracheal components: C-shaped cartilage ring, O-shaped vascularized fiber ring, axial fiber bundle, and airway epithelium. Overall, the MI-TET demonstrates highly similar multi-tissue structures and physiological functions to natural trachea, showing promise for future clinical advancements in functional TETs.
Authors
- Xingqi Song (ORCID: https://orcid.org/0000-0002-2845-2346)
- Sinan Wang (ORCID: https://orcid.org/0009-0001-9975-6064)
- Yixin Zhang (ORCID: https://orcid.org/0000-0003-4632-3780)
- Guangdong Zhou (ORCID: https://orcid.org/0000-0003-2488-2733)
- Xiaohong Qin (ORCID: https://orcid.org/0000-0003-4663-903X)
- Dong Lei (ORCID: https://orcid.org/0000-0003-3264-9835)
- Peiling Zhang (ORCID: https://orcid.org/0000-0001-8655-7093)
- Ke Li (ORCID: https://orcid.org/0000-0003-2446-2085)
- Bin Luo (ORCID: https://orcid.org/0009-0006-1768-1529)
- Jinyi Huang (ORCID: https://orcid.org/0009-0005-5356-324X)
- Yü Liu (ORCID: https://orcid.org/0009-0002-9687-2729)
- Qianyi Wang (ORCID: https://orcid.org/0000-0002-3679-4792)
Institutions
- Donghua University (CN)
- Shanghai Jiao Tong University (CN)
Publication Details
- Journal
- Advanced Science
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1002/advs.202405420
- Citations
- 7
- Primary Topic
- Tracheal and airway disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.93
Funders
- National Natural Science Foundation of China
- Shanghai Jiao Tong University
- School of Medicine, Shanghai Jiao Tong University
- National Key Research and Development Program of China