Expression of human Interferon Regulatory Factor 3 (IRF-3) in alveolar macrophages relates to clinical and functional traits in COPD.
Smoking is associated with higher levels of innate immune response as showed by higher levels of IRF-3 + alveolar macrophages and NKp46 + cells. In COPD, exacerbation rates, severe airflow obstruction and CB were associated with lower levels of IRF-3 expression, suggesting that innate immune responses characterize specific clinical traits of the disease.
Authors
- Simonetta Baraldo (ORCID: https://orcid.org/0000-0001-8923-7511)
- Marco Contoli (ORCID: https://orcid.org/0000-0002-2731-5809)
- Paolo Casolari (ORCID: https://orcid.org/0000-0002-7848-1217)
- Tommaso Bigoni (ORCID: https://orcid.org/0000-0003-1970-9653)
- Matteo Bonato (ORCID: https://orcid.org/0000-0002-1796-8478)
- Fulvio Braido (ORCID: https://orcid.org/0000-0003-2460-4709)
- Alberto Papi (ORCID: https://orcid.org/0000-0002-6924-4500)
- Sebastiano Cassia
- Marina Saetta (ORCID: https://orcid.org/0000-0002-1547-2102)
- A Riccio (ORCID: https://orcid.org/0000-0001-8392-533X)
- Federico Baraldi (ORCID: https://orcid.org/0009-0007-5649-8409)
- Mariaenrica Tinè (ORCID: https://orcid.org/0000-0002-3094-5721)
- Laura De Ferrari (ORCID: https://orcid.org/0000-0002-4872-218X)
Institutions
- University of Padua (IT)
- University of Ferrara (IT)
- Azienda Unità Sanitaria Locale di Ferrara (IT)
- Arcispedale Sant'Anna (IT)
- Ca' Foncello Hospital (IT)
- Ospedale Policlinico San Martino (IT)
- University of Genoa (IT)
Publication Details
- Journal
- Respiratory Research
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1186/s12931-024-02952-6
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00