Pulmonary adaptation to repeated poly(I:C) exposure is impaired in asthmatic mice: an observational study
This observational study report an asthmatic mouse model that can undergo exacerbation after repeated exposure to poly(I:C). Our findings on pulmonary adaptation in control mice may also pave the way for further research into the mechanism of adaptation that may be impaired in asthma and raise the question of whether asthma exacerbation may be a loss of adaptation.
Authors
- Olga Ousova
- Benoît Allard (ORCID: https://orcid.org/0000-0002-7093-5851)
- Élise Maurat
- Hannah Levardon
- Patrick Berger (ORCID: https://orcid.org/0000-0003-4702-0343)
- Zhanna Savitskaya
- Thomas Trian (ORCID: https://orcid.org/0000-0002-2567-4867)
- Marilyne Campagnac
Institutions
- Inserm (FR)
- Centre Hospitalier Universitaire de Bordeaux (FR)
- Centre de Recherche Cardio-Thoracique de Bordeaux (FR)
Publication Details
- Journal
- Respiratory Research
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1186/s12931-024-02948-2
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Centre National de la Recherche Scientifique