Electrophysiological Mechanism of Catestatin Antiarrhythmia: Enhancement of <i>I</i> <sub>to</sub> , <i>I</i> <sub>K,</sub> and <i>I</i> <sub>K1</sub> and Inhibition of <i>I</i> <sub>Ca</sub> <sub>‐L</sub> in Rat Ventricular Myocytes
Catestatin enhances the activity of transient outward potassium current, delayed rectifier potassium current, and inward rectifying potassium current, while suppressing the <i>I</i><sub>Ca-L</sub> in ventricular myocytes, leading to shortened action potential duration and ultimately reducing the ventricular arrhythmia in rats.
Authors
- Qingmin Ma
- Huijie Ma (ORCID: https://orcid.org/0000-0002-6069-349X)
- Hongyu Ma
- Hui Jia (ORCID: https://orcid.org/0009-0004-4417-7809)
- Yi Zhang (ORCID: https://orcid.org/0000-0001-8605-9377)
- Yan Liu (ORCID: https://orcid.org/0000-0003-4097-8049)
- Ying Zhang
- Zheng‐Fang Du
- Yue Guan (ORCID: https://orcid.org/0009-0001-6075-5144)
- Hua Chen (ORCID: https://orcid.org/0000-0002-0395-266X)
- Xiangjian Zhang (ORCID: https://orcid.org/0000-0003-0114-1668)
Institutions
- Hebei Medical University (CN)
- Third Hospital of Hebei Medical University (CN)
- Hebei General Hospital (CN)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1161/jaha.124.035415
- Citations
- 2
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.80