SelK promotes glioblastoma cell proliferation by inhibiting β-TrCP1 mediated ubiquitin-dependent degradation of CDK4
This study discovered a significant increase in SelK expression in GB patients with poor prognosis, revealing a negative correlation between SelK expression and patient outcomes. Further mechanistic investigations revealed that SelK enhances the proliferation of GB cells by targeting the endoplasmic reticulum stress/SKP2/β-TrCP1/CDK4 axis.
Authors
- Chuanshu Huang
- Jizhen Li (ORCID: https://orcid.org/0000-0003-1940-5633)
- Yuanyuan Chang (ORCID: https://orcid.org/0000-0001-8562-3781)
- Haishan Huang (ORCID: https://orcid.org/0000-0002-7094-9786)
- Zhipeng Su (ORCID: https://orcid.org/0000-0002-0794-4122)
- Jianglong Lu (ORCID: https://orcid.org/0000-0001-7984-2582)
- Qipeng Xie (ORCID: https://orcid.org/0000-0002-3292-2988)
- Zerui Wu (ORCID: https://orcid.org/0000-0003-4769-2430)
- Shirui Huang (ORCID: https://orcid.org/0009-0005-6607-0313)
- Junyu Wang (ORCID: https://orcid.org/0000-0003-4605-2423)
- Lingling Zhao (ORCID: https://orcid.org/0000-0002-0835-4378)
- Honglei Jin (ORCID: https://orcid.org/0000-0002-2541-8855)
- Li Liu
Institutions
- Fudan University (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (CN)
- Jinhua Academy of Agricultural Sciences (CN)
- Guang Fu Hospital (CN)
- Huashan Hospital (CN)
- Jinhua Central Hospital (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1186/s13046-024-03157-x
- Citations
- 6
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Wenzhou Medical University
- York University
- School of Medicine, New York University