Insights into macrolide resistance in <i>Arcobacter butzleri</i>: potential resistance mechanisms and impact on bacterial fitness and virulence
The findings of this study have proved that efflux activity contributes synergistically with mutations in the ribosomal proteins L4 and L22 to A. butzleri's high-level macrolide resistance. The results further suggest an impact on the bacterial physiology and virulence, with the increased fitness cost justifying the low worldwide prevalence of high-level resistant circulating strains.
Authors
- Susana Ferreira (ORCID: https://orcid.org/0000-0001-8308-2862)
- Filipa F. Vale (ORCID: https://orcid.org/0000-0003-4635-0105)
- Fernanda Domingues (ORCID: https://orcid.org/0000-0002-9540-0853)
- Inês Martins (ORCID: https://orcid.org/0000-0001-6278-0928)
- Mónica Oleastro (ORCID: https://orcid.org/0000-0001-6360-2576)
- Francisca Couto
Institutions
- University of Lisbon (PT)
- University of Beira Interior (PT)
- National Institute of Health Dr. Ricardo Jorge (PT)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1093/jac/dkae287
- Citations
- 4
- Primary Topic
- Salmonella and Campylobacter epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Fundação para a Ciência e a Tecnologia