Pitavastatin Is Well-Tolerated With no Detrimental Effects on Physical Function
We observed minimal declines in physical function over 5 years of follow-up among middle-aged PWH, with no differences among PWH randomized to pitavastatin compared to placebo. This finding, combined with low prevalence of myalgias, supports the long-term safety of statin therapy on physical function, when used for primary prevention of major adverse cardiovascular events among PWH.
Authors
- Markella V. Zanni (ORCID: https://orcid.org/0000-0002-4711-3956)
- Kristine Mace Erlandson (ORCID: https://orcid.org/0000-0003-0808-6729)
- Heather J. Ribaudo (ORCID: https://orcid.org/0000-0002-0394-3990)
- Carl J. Fichtenbaum (ORCID: https://orcid.org/0000-0002-6778-7253)
- Maria C. Rodriguez‐Barradas (ORCID: https://orcid.org/0000-0003-2446-2667)
- Edgar T. Overton (ORCID: https://orcid.org/0000-0002-4013-536X)
- Rosalba Gomez Morones
- Pamela S. Douglas (ORCID: https://orcid.org/0000-0001-9876-4049)
- Steven Grinspoon (ORCID: https://orcid.org/0000-0002-6338-000X)
- Todd T. Brown (ORCID: https://orcid.org/0000-0001-8599-278X)
- Triin Umbleja (ORCID: https://orcid.org/0000-0001-7161-7743)
- Carlos Malvestutto (ORCID: https://orcid.org/0000-0003-3156-2965)
- Gerald S. Bloomfield (ORCID: https://orcid.org/0000-0002-7176-1611)
- Jennifer A. Schrack (ORCID: https://orcid.org/0000-0001-9244-9267)
- Jhoanna C. Roa
- Marissa R Diggs
- Kathleen V. Fitch (ORCID: https://orcid.org/0000-0002-0541-3707)
- Judith A. Aberg (ORCID: https://orcid.org/0000-0001-8162-0284)
- Kenneth W. Wood
- K. Breaux
Institutions
- Michael E. DeBakey VA Medical Center (US)
- Harvard University (US)
- Johns Hopkins University (US)
- Duke University (US)
- Baylor College of Medicine (US)
- The Ohio State University Wexner Medical Center (US)
- University of Alabama at Birmingham (US)
- Massachusetts General Hospital (US)
- Clinical Research Institute (US)
- Columbus Oncology and Hematology Associates (US)
- Cancer Research And Biostatistics (US)
- Frontier Science & Technology Research Foundation, Inc. (US)
- Durham VA Medical Center (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Cincinnati Medical Center (US)
- University of Colorado Denver (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1093/cid/ciae422
- Citations
- 3
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 1.72
Funders
- Gilead Sciences
- ViiV Healthcare
- Norges Idrettshøgskole
- Nutrition Obesity Research Center at Harvard
- National Institute on Aging
- National Institute of Allergy and Infectious Diseases