Low-level HIV-1 viremia affects T-cell activation and senescence in long-term treated adults in the INSTI era
LLV between 50 and 200 copies/mL leads to reduced cytotoxic activity and T-cell dysfunction that could affect cytokine production, being unable to control and eliminate infected cells. The increase in senescence markers suggests a progressive loss of immunological memory and a reduction in the proliferative capacity of immune cells. This accelerated immune aging could lead to an increased risk of developing future comorbidities. These findings strongly advocate for heightened surveillance of these PWH to promptly identify potential future complications.
Authors
- Mario Alía (ORCID: https://orcid.org/0000-0002-0695-4038)
- Amanda Fernández‐Rodríguez (ORCID: https://orcid.org/0000-0002-5110-2213)
- Oscar Brochado‐Kith (ORCID: https://orcid.org/0000-0001-8372-2604)
- Ignacio de los Santos (ORCID: https://orcid.org/0000-0001-7073-5211)
- Verónica Briz (ORCID: https://orcid.org/0000-0003-2297-5098)
- Violeta Lara‐Aguilar (ORCID: https://orcid.org/0000-0003-0015-5961)
- Sonia Arca-Lafuente (ORCID: https://orcid.org/0000-0003-4750-0988)
- C. M. C. O. PRADO
- Celia Crespo‐Bermejo (ORCID: https://orcid.org/0000-0002-2813-2481)
- Luz Martı́n-Carbonero (ORCID: https://orcid.org/0000-0001-8102-4079)
- Sergio Grande‐García
- Manuel Llamas-Adán (ORCID: https://orcid.org/0000-0003-3855-5872)
- Ricardo Madrid (ORCID: https://orcid.org/0000-0002-1350-9864)
- Coral Sainz-Pinós
Institutions
- Universidad Complutense de Madrid (ES)
- Hospital Universitario La Paz (ES)
- Instituto de Salud Carlos III (ES)
- Hospital La Paz Institute for Health Research (ES)
- Centro de Investigación Biomédica en Red (ES)
- Hospital Universitario de La Princesa (ES)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1186/s12929-024-01064-z
- Citations
- 8
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.35
Funders
- Instituto de Salud Carlos III