Performance of plasma p-tau217 for the detection of amyloid-β positivity in a memory clinic cohort using an electrochemiluminescence immunoassay
Plasma p-tau217 measured using a high-sensitivity ECL immunoassay demonstrated excellent performance for detection of Aβ pathology in a real-world memory clinic cohort. Moving forward, clinical use of plasma p-tau217 to detect AD pathology may substantially reduce need for confirmatory diagnostic testing for AD pathology with diagnostic LP in specialist memory services.
Authors
- Helena Dolphin (ORCID: https://orcid.org/0000-0001-5540-7850)
- Laura Morrison (ORCID: https://orcid.org/0000-0002-9610-9435)
- Antoinette O’Connor (ORCID: https://orcid.org/0000-0003-4467-128X)
- Christine Gaffney
- Nollaig M. Bourke (ORCID: https://orcid.org/0000-0003-4313-6859)
- Aoife McFeely
- Seán O’Dowd (ORCID: https://orcid.org/0000-0002-5102-6230)
- Naomi Davey
- Shane Lyons (ORCID: https://orcid.org/0000-0001-8381-7531)
- Adam H. Dyer (ORCID: https://orcid.org/0000-0003-1356-510X)
- Cathy McHale
- Graham Knight
- Emmet Kelly (ORCID: https://orcid.org/0000-0001-5145-860X)
- Paul Claffey (ORCID: https://orcid.org/0000-0002-2839-1272)
- Jasmine Joseph (ORCID: https://orcid.org/0000-0001-6319-5210)
- Aoife Fallon (ORCID: https://orcid.org/0000-0002-2912-7297)
- Seán Kennelly (ORCID: https://orcid.org/0000-0002-3721-0197)
- Emily Killeen (ORCID: https://orcid.org/0000-0001-8316-5895)
- Conal Gallagher
- Cliona O’Farrelly (ORCID: https://orcid.org/0000-0002-0616-2874)
- Gavin Sedgwick
- Eimear Connolly (ORCID: https://orcid.org/0000-0002-9896-8305)
- Conor Young
- Ruth Ennis
- Paddy Doyle
Institutions
- Trinity College (CA)
- Trinity College Dublin (IE)
- Tallaght University Hospital (IE)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1186/s13195-024-01555-z
- Citations
- 26
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 8.49
Funders
- Canadian Institute for Theoretical Astrophysics
- Wellcome Trust
- Health Research Board
- Health Service Executive
- Meath Foundation