An observational cohort study to investigate the impact of dolutegravir in pregnancy and its obesogenic effects on the metabolic health of women living with HIV and their children: Study protocol
ORCHID will play a pivotal role in defining obesogenic mechanisms and clinical consequences of DTG use in pregnancy in women with HIV and their children. It will provide insights into metabolic disease risk reduction in the context of HIV/DTG, identify intervention targets, and inform public health approaches to diminish chronic metabolic co-morbidities for women and children.
Authors
- Grace A. McComsey (ORCID: https://orcid.org/0000-0003-2690-8888)
- Allison Zerbe (ORCID: https://orcid.org/0000-0002-3372-6882)
- Jennifer Jao
- Patrick M. Catalano (ORCID: https://orcid.org/0000-0003-1276-7017)
- Elton Mukonda (ORCID: https://orcid.org/0000-0002-3930-3389)
- Mariana Gerschenson (ORCID: https://orcid.org/0000-0002-8615-5964)
- Daniel T. Robinson (ORCID: https://orcid.org/0000-0003-2450-9680)
- Yolanda Gomba
- Jami L. Josefson (ORCID: https://orcid.org/0000-0003-0339-0166)
- Elaine J. Abrams (ORCID: https://orcid.org/0000-0001-7938-8981)
- Irwin J. Kurland (ORCID: https://orcid.org/0000-0002-9633-1917)
- Landon Myer (ORCID: https://orcid.org/0000-0002-8106-7658)
- Julia H. Goedecke (ORCID: https://orcid.org/0000-0001-6795-4771)
- Hlengiwe P. Madlala (ORCID: https://orcid.org/0000-0001-7759-3498)
- Justine Legbedze
- Sandisiwe Matyesini
Institutions
- South African Medical Research Council (ZA)
- Northwestern University (US)
- University of Hawaiʻi at Mānoa (US)
- Tufts University (US)
- Albert Einstein College of Medicine (US)
- University of Cape Town (ZA)
- University Health System (US)
- Case Western Reserve University (US)
- Columbia University (US)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1371/journal.pone.0307296
- Citations
- 6
- Primary Topic
- HIV-related health complications and treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.15
Funders
- National Institutes of Health
- Eunice Kennedy Shriver National Institute of Child Health and Human Development