Identification of microbial antigens in liver tissues involved in the pathogenesis of primary biliary cholangitis using 16S rRNA metagenome analysis
S. panacis antigen was specifically detected in the portal areas of PBC liver tissues. The introduction of foreign-derived antigens into the liver as an environmental factor could be a possible mechanism for the development of PBC.
Authors
- Ryoko Murakami (ORCID: https://orcid.org/0009-0005-8909-5441)
- Hiroaki Haga (ORCID: https://orcid.org/0000-0001-9355-1837)
- Takafumi Saito (ORCID: https://orcid.org/0000-0002-1169-0970)
- Kyoko Hoshikawa
- Tomohiro Katsumi (ORCID: https://orcid.org/0000-0001-5670-7505)
- Yoshiyuki Ueno (ORCID: https://orcid.org/0000-0001-5623-4250)
- Hidenori Sato
- Keita Maki (ORCID: https://orcid.org/0009-0003-2035-1940)
- Fumi Uchiyama
- Takumi Hanatani
- Fumiya Suzuki
Institutions
- Yamagata University (JP)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1371/journal.pone.0308912
- Citations
- 4
- Primary Topic
- Liver Diseases and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 1.48
Funders
- Ministry of Health and Welfare
- Ministry of Health, Labour and Welfare
- Japan Society for the Promotion of Science