Schistosomicidal effects of histone acetyltransferase inhibitors against Schistosoma japonicum juveniles and adult worms in vitro
Among the three commercially available HATs, curcumin was the most potent against schistosomes. Both curcumin and our patent compound DW-3-15 markedly downregulated the expression of SjHAT, indicating that SjHAT may be a potential therapeutic target for developing novel antischistosomal drug candidates.
Authors
- Chao-Ming Xia (ORCID: https://orcid.org/0000-0003-3541-488X)
- Run-Ze Zhang
- Yuxin Wang (ORCID: https://orcid.org/0000-0002-6087-6544)
- Chunrong Xiong
- Ping Huang (ORCID: https://orcid.org/0000-0002-7391-1441)
- Xiaoyan Ni (ORCID: https://orcid.org/0000-0002-1651-5530)
- Huimin Ma (ORCID: https://orcid.org/0000-0001-9376-2095)
- Jing Xu (ORCID: https://orcid.org/0000-0002-4620-2025)
- Zi-Hao Liu (ORCID: https://orcid.org/0009-0006-0537-6631)
- Bi-Yue Zhou
- Jingyi Wang (ORCID: https://orcid.org/0000-0002-4432-5443)
Institutions
- Soochow University (CN)
- Jiangsu Institute of Parasitic Diseases (CN)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1371/journal.pntd.0012428
- Citations
- 4
- Primary Topic
- Parasites and Host Interactions
- Type
- article
- Field-Weighted Citation Impact
- 2.06
Funders
- National Natural Science Foundation of China
- Soochow University
- Priority Academic Program Development of Jiangsu Higher Education Institutions