Single-Cell Transcriptomic Profiling of Cholangiocyte Organoids Derived from Bile Ducts of Primary Sclerosing Cholangitis Patients
Our results demonstrate that PSC organoids are largely similar to control organoids after culture and highlight the significance of COs as a tool for regenerative medicine approaches as well as their potential for discovering new potential biomarkers for diagnosing cholangiocarcinoma.
Authors
- Fotios Sampaziotis (ORCID: https://orcid.org/0000-0003-0812-7586)
- Teresa Brevini (ORCID: https://orcid.org/0000-0002-3581-5379)
- Anna Katharina Frank (ORCID: https://orcid.org/0000-0003-1378-5129)
- Tom H. Karlsen (ORCID: https://orcid.org/0000-0002-8289-9931)
- Jan S. Tchorz (ORCID: https://orcid.org/0000-0003-1745-6621)
- Irina Mohorianu (ORCID: https://orcid.org/0000-0003-4863-761X)
- Ludovic Vallier (ORCID: https://orcid.org/0000-0002-3848-2602)
- Espen Melum
- Lise Katrine Engesæter
- Brian K. Chung (ORCID: https://orcid.org/0000-0002-9523-7515)
- Olivia Tysoe (ORCID: https://orcid.org/0000-0002-1061-1484)
- James A. Heslop (ORCID: https://orcid.org/0000-0002-8888-8977)
- Jonas Øgaard (ORCID: https://orcid.org/0000-0001-9194-5939)
- Henry William Hoyle
- Miguel Larraz Lopez De Novales
Institutions
- Oslo University Hospital (NO)
- Novartis (Switzerland) (CH)
- University of Oslo (NO)
- Wellcome/MRC Cambridge Stem Cell Institute (GB)
- University of Cambridge (GB)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Max Planck Institute for Molecular Genetics (DE)
- Medical Research Council (GB)
Publication Details
- Journal
- Digestive Diseases and Sciences
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1007/s10620-024-08570-y
- Citations
- 9
- Primary Topic
- Liver Diseases and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 3.33
Funders
- European Commission
- Universitetet i Oslo
- Norges Forskningsråd
- Medical Research Council