Navigating Hemolysis and the Renal Implications of Hemoglobin Toxicity in Cardiac Surgery
Cardiopulmonary bypass–induced hemolysis is linked to acute kidney injury in cardiac surgery. Emerging therapies targeting cell-free hemoglobin (CFHb), like haptoglobin, nitric oxide (NO), and antioxidants, show promise in reducing kidney injury, highlighting the need for further research.
Authors
- Kenichi A. Tanaka (ORCID: https://orcid.org/0000-0002-5051-1365)
- Dominik J. Schaer (ORCID: https://orcid.org/0000-0002-6468-4013)
- Jerrold H. Levy (ORCID: https://orcid.org/0000-0003-3766-4962)
- Florence Vallelian (ORCID: https://orcid.org/0000-0001-9659-8278)
- Reney Henderson (ORCID: https://orcid.org/0000-0003-4701-5827)
- Christian A. Schaer (ORCID: https://orcid.org/0000-0001-6114-0750)
- Rok Humar (ORCID: https://orcid.org/0000-0002-5393-9455)
- Paul W. Buehler (ORCID: https://orcid.org/0000-0003-0687-3008)
Institutions
- University of Maryland, Baltimore (US)
- Duke University (US)
- University of Zurich (CH)
- University Hospital of Zurich (CH)
- Duke University Hospital (US)
- University of Oklahoma Health Sciences Center (US)
Publication Details
- Journal
- Anesthesiology
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1097/aln.0000000000005109
- Citations
- 8
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- National Science Foundation
- CSL Behring
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- National Institutes of Health
- National Heart, Lung, and Blood Institute