Membrane-free stem cell components suppress osteoclast differentiation: Implications for oral regenerative treatment
Our findings demonstrate that MFSCCs suppress osteoclast differentiation by downregulating transcription factors, particularly, c-fos and NFATc1. Therefore, MFSCCs may serve as a conservative treatment option for chronic inflammatory bone resorption diseases of the oral cavity by suppressing excessive bone resorption.
Authors
- Sang Hun Shin (ORCID: https://orcid.org/0000-0002-3290-4261)
- Jin‐Ju Kwon (ORCID: https://orcid.org/0000-0002-3522-590X)
- Eun-Jung Kim (ORCID: https://orcid.org/0000-0003-4982-9517)
- Mi Kyoung Kim (ORCID: https://orcid.org/0000-0002-7717-0310)
- Sang-Wook Ahn
Institutions
- Pusan National University Dental Hospital (KR)
- Pusan National University Yangsan Hospital (KR)
- Yeungnam University College
- Yeungnam University (KR)
Publication Details
- Journal
- Journal of Dental Sciences
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1016/j.jds.2024.08.005
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Yeungnam University
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea