The Hippo Coactivator TAZ Exacerbates Cisplatin-Induced Acute Renal Injury
Our findings show that cisplatin-induced AKI and tubular cell ferroptosis are mediated by TAZ-PPARδ interaction through regulation of GPX4, highlighting TAZ as a potential therapeutic candidate for AKI.
Authors
- Lu Zhou (ORCID: https://orcid.org/0009-0001-8695-6606)
- Mengzhu Tan
- Mengru Gu
- Sudan Wang
- Xingwen Zhu
- Chunsun Dai (ORCID: https://orcid.org/0000-0001-7616-2469)
- Xiaoli Sun (ORCID: https://orcid.org/0000-0002-7286-0435)
- Qing Hou
- Xian Xue
- Yan Liang
Institutions
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Kidney Diseases
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1159/000540973
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- National Natural Science Foundation of China
- Government of Jiangsu Province
- University of Texas MD Anderson Cancer Center