Transcriptomic profiling of the oocyte-cumulus-granulosa cell complex from estrogen receptor β knockout mice
Our results show that ERβ has an important role in regulating ovulation in response to exogenous gonadotropins in 6-month-old mice, but not in younger mice. Our transcriptomic and immunohistochemical observations suggest a dysregulation of the granulosa cell communication and lack of tight coordination between granulosa cell replication and antrum expansion. A significant upregulation of other estrogen receptors may support a compensatory mechanism sustaining fertility during younger age in Esr2-KO mice.
Authors
- Nageswara Rao Boggavarapu (ORCID: https://orcid.org/0000-0002-8588-8445)
- Per Antonson (ORCID: https://orcid.org/0000-0001-9335-9941)
- Virpi Töhönen
- Ivan Nalvarte (ORCID: https://orcid.org/0000-0001-6828-2583)
- Kenny A. Rodriguez‐Wallberg (ORCID: https://orcid.org/0000-0003-4378-6181)
- Shintaro Katayama (ORCID: https://orcid.org/0000-0001-7581-5157)
- Mukesh Varshney (ORCID: https://orcid.org/0000-0003-2165-0152)
- Jan-Ακε Gustafsson (ORCID: https://orcid.org/0000-0002-1472-1373)
- José Inzunza (ORCID: https://orcid.org/0000-0003-0876-6767)
- Heba Ali (ORCID: https://orcid.org/0000-0001-5535-7638)
- Leticia Apolinario Motaholi
Institutions
- Karolinska University Hospital (SE)
- Karolinska Institutet (SE)
- Integrated Cardio Metabolic Centre (SE)
- Folkhälsans Forskningscentrum (FI)
- Assiut University (EG)
Publication Details
- Journal
- F&S Science
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1016/j.xfss.2024.08.004
- Citations
- 2
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 1.09
Funders
- Cancerfonden
- IngaBritt och Arne Lundbergs Forskningsstiftelse
- Karolinska Institutet
- Novo Nordisk
- Vetenskapsrådet
- Radiumhemmets Forskningsfonder