Dialog between mantle cell lymphoma cells and lymphoma-associated macrophages underlies ibrutinib resistance
Our data indicate that M2-polarized LAMs are associated with ibrutinib resistance in a model of MCL, and that a CXCR2 inhibitor can reverse this resistance. These findings suggest a potential new therapeutic strategy.
Authors
- Zhiming Li (ORCID: https://orcid.org/0000-0001-9730-9917)
- Peng Sun (ORCID: https://orcid.org/0000-0003-3811-0371)
- Robert Peter Gale (ORCID: https://orcid.org/0000-0002-9156-1676)
- Jing Li (ORCID: https://orcid.org/0000-0001-7792-4322)
- Yu Wang (ORCID: https://orcid.org/0009-0006-9915-7092)
- Xiaoqing Sun (ORCID: https://orcid.org/0000-0001-8099-0216)
- Caiqin Wang
- Jiajia Huang
- Jianghua Cao
- Xianqiu Wu
- Gang Ma (ORCID: https://orcid.org/0009-0008-4141-5559)
Institutions
- Central South University (CN)
- Sun Yat-sen University (CN)
- Nanfang Hospital (CN)
- Hunan Cancer Hospital (CN)
- Sun Yat-sen University Cancer Center (CN)
- Imperial College London (GB)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1016/j.jare.2024.08.023
- Citations
- 6
- Primary Topic
- Chronic Lymphocytic Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 2.63
Funders
- NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research
- National Institute for Health and Care Research
- National Natural Science Foundation of China
- Sun Yat-sen University
- Ministry of Science and Technology of the People's Republic of China
- National Science and Technology Major Project
- Guangzhou Science and Technology Program key projects
- Guangzhou Municipal Science and Technology Project
- National Major Science and Technology Projects of China
- Sun Yat-sen University Cancer Center