Conditional deletion of CEACAM1 in hepatic stellate cells causes their activation

Loss of CEACAM1 in HSCs provoked their myofibroblastic transformation in the absence of insulin resistance and hepatic steatosis. This response is mediated by autocrine HSCs activation of the EGFR pathway that amplifies inflammation and proliferation.

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Publication Details

Journal
Molecular Metabolism
Published
2024-08-19
DOI
https://doi.org/10.1016/j.molmet.2024.102010
Citations
12
Primary Topic
Liver physiology and pathology
Type
article
Field-Weighted Citation Impact
4.43

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article

Conditional deletion of CEACAM1 in hepatic stellate cells causes their activation

Leo A. van Grunsven, Raziyeh Abdolahipour, Sumona Ghosh Lester, Sobia Zaidi et al.
12 citations
Molecular Metabolism
Liver physiology and pathology
4.43
article

Conditional deletion of CEACAM1 in hepatic stellate cells causes their activation

Leo A. van Grunsven, Raziyeh Abdolahipour, Sumona Ghosh Lester, Sobia Zaidi, Ali Zarrinpar, Sivarajan Kumarasamy, Getachew D. Belew, Suman Asalla, Terry D. Hinds, Hilda E. Ghadieh, Hannah L. Stankus, Stefaan Verhulst, Raghd Abu Helal, Harrison T. Muturi, Robert F. Schwabe, Sérgio M. Duarte, Scott L. Friedman, Sonia Michael Najjar, Abhishek P Shrestha, Agnes O Portuphy
article en
12 citations

Abstract

Loss of CEACAM1 in HSCs provoked their myofibroblastic transformation in the absence of insulin resistance and hepatic steatosis. This response is mediated by autocrine HSCs activation of the EGFR pathway that amplifies inflammation and proliferation.

Molecular MetabolismVol. 88
Vrije Universiteit Brussel (BE), University of Kentucky (US), University of Balamand (LB), University of Florida (US), Ohio University (US), Columbia University (US), University of Toledo (US), Icahn School of Medicine at Mount Sinai (US)
Osteopathic Heritage Foundation, Fonds Wetenschappelijk Onderzoek, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases
Zero hunger
Openalex Percentile: Top 5%
Liver physiology and pathology
4.43
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