Conditional deletion of CEACAM1 in hepatic stellate cells causes their activation
Loss of CEACAM1 in HSCs provoked their myofibroblastic transformation in the absence of insulin resistance and hepatic steatosis. This response is mediated by autocrine HSCs activation of the EGFR pathway that amplifies inflammation and proliferation.
Authors
- Leo A. van Grunsven (ORCID: https://orcid.org/0000-0002-0990-7034)
- Raziyeh Abdolahipour
- Sumona Ghosh Lester
- Sobia Zaidi (ORCID: https://orcid.org/0000-0003-0289-6413)
- Ali Zarrinpar (ORCID: https://orcid.org/0000-0002-6812-1816)
- Sivarajan Kumarasamy (ORCID: https://orcid.org/0000-0003-1327-2294)
- Getachew D. Belew (ORCID: https://orcid.org/0000-0002-7338-1938)
- Suman Asalla (ORCID: https://orcid.org/0000-0001-9636-3161)
- Terry D. Hinds (ORCID: https://orcid.org/0000-0002-7599-1529)
- Hilda E. Ghadieh (ORCID: https://orcid.org/0000-0002-7983-2090)
- Hannah L. Stankus
- Stefaan Verhulst (ORCID: https://orcid.org/0000-0001-6566-6071)
- Raghd Abu Helal
- Harrison T. Muturi
- Robert F. Schwabe (ORCID: https://orcid.org/0000-0003-4571-2098)
- Sérgio M. Duarte (ORCID: https://orcid.org/0000-0003-1036-6850)
- Scott L. Friedman (ORCID: https://orcid.org/0000-0003-1178-6195)
- Sonia Michael Najjar (ORCID: https://orcid.org/0000-0001-6209-8902)
- Abhishek P Shrestha (ORCID: https://orcid.org/0000-0003-1576-8584)
- Agnes O Portuphy (ORCID: https://orcid.org/0009-0009-9007-7741)
Institutions
- Vrije Universiteit Brussel (BE)
- University of Kentucky (US)
- University of Balamand (LB)
- University of Florida (US)
- Ohio University (US)
- Columbia University (US)
- University of Toledo (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1016/j.molmet.2024.102010
- Citations
- 12
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 4.43
Funders
- Osteopathic Heritage Foundation
- Fonds Wetenschappelijk Onderzoek
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases