Development of Axially Chiral Pyridylidene Amine Ligands and their Application in Pd-Catalyzed Enantioselective Allylic Substitution
A series of novel axially chiral pyridylidene amine (PYE) ligands has been developed, and their catalytic capability has been demonstrated in various highly efficient and enantioselective Pd-catalyzed asymmetric allylic substitutions. A density-functional theory (DFT) study explains the preferential enantiocontrol in the key transition states of the axially chiral PYE ligand-promoted Pd-catalyzed allylic alkylation.
Authors
- Terumasa Kato (ORCID: https://orcid.org/0000-0001-6914-9389)
- Keiji Maruoka (ORCID: https://orcid.org/0000-0002-0044-6411)
- Jiahao Liu (ORCID: https://orcid.org/0000-0002-7820-042X)
- Yan Liu (ORCID: https://orcid.org/0000-0002-3864-1992)
- Zhe Wang (ORCID: https://orcid.org/0000-0002-7854-8207)
- Zhikang Chen (ORCID: https://orcid.org/0009-0003-2568-6184)
- Weiying Ou
- Yong Chen
Institutions
- Guangdong University of Technology (CN)
- Kyoto University (JP)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1021/acs.joc.4c01334
- Citations
- 6
- Primary Topic
- Axial and Atropisomeric Chirality Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 1.50
Funders
- National Natural Science Foundation of China
- Guangdong Provincial Pearl River Talents Program
- Japan Society for the Promotion of Science