Amine-Borane-Mediated, Nickel/Photoredox-Catalyzed Cross-Electrophile Coupling between Alkyl and Aryl Bromides
Nickel/photoredox catalysis has emerged as a powerful platform for exploring nontraditional and challenging cross-couplings. Herein, a metallaphotoredox catalytic protocol has been developed on the basis of a tertiary amine-ligated boryl radical-induced halogen atom transfer process under blue-light irradiation. A wide variety of aryl and heteroaryl bromides featuring different functional groups and pharmaceutical moieties were facilely coupled to rapidly install C(sp<sup>3</sup>)-enriched aromatic scaffolds. The compatibility of Lewis base-ligated borane with nickel catalysis was well exemplified to extend the chemical space for Ni-catalyzed cross-electrophile coupling.
Authors
- Xian‐Chen He
- Hao‐Yue Xiang (ORCID: https://orcid.org/0000-0002-7404-4247)
- Hua Yang (ORCID: https://orcid.org/0000-0002-5518-5255)
- Kai Chen (ORCID: https://orcid.org/0000-0003-1012-0383)
- Hong‐Bin Chen
- Yanling Liu (ORCID: https://orcid.org/0000-0002-5173-2426)
- Ke-Rong Li
- Jie Gao (ORCID: https://orcid.org/0000-0002-1945-3048)
Institutions
- Central South University (CN)
- Shanghai Zhangjiang Laboratory (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1021/acs.joc.4c01605
- Citations
- 15
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 3.75
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province
- Fundamental Research Funds for Central Universities of the Central South University