Identification of energy metabolism anomalies and serum biomarkers in the progression of premature ovarian failure via extracellular vesicles’ proteomic and metabolomic profiles
Omics analysis revealed that inflammation, oxidative stress, and hormone imbalance are factors that damage ovarian tissue, but the progressive dysfunction of energy metabolism might be the critical pathogenic pathway contributing to the development of POF. AFM combined with 2-oxoarginine serves as a precise biomarker for clinical POF diagnosis.
Authors
- Desheng Lu (ORCID: https://orcid.org/0000-0002-0314-5649)
- Zhengdong Liao
- Hongyu Zhao (ORCID: https://orcid.org/0000-0003-1195-9607)
- Qi‐Lin Zhou (ORCID: https://orcid.org/0000-0002-4700-3765)
- Liangge He
- Sheng Yang (ORCID: https://orcid.org/0000-0003-4226-2159)
- Wenchao Zheng (ORCID: https://orcid.org/0000-0003-3665-3364)
- Zhen Liu
- Yajing Cha
Institutions
- Shenzhen University (CN)
- Shenzhen Third People’s Hospital (CN)
Publication Details
- Journal
- Reproductive Biology and Endocrinology
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1186/s12958-024-01277-9
- Citations
- 6
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Natural Science Foundation of Guangdong Province
- Shenzhen Fundamental Research Program
- Shenzhen Science and Technology Innovation Program