Heterogeneous orientation tuning in the primary visual cortex of mice diverges from Gabor-like receptive fields in primates
A key feature of neurons in the primary visual cortex (V1) of primates is their orientation selectivity. Recent studies using deep neural network models showed that the most exciting input (MEI) for mouse V1 neurons exhibit complex spatial structures that predict non-uniform orientation selectivity across the receptive field (RF), in contrast to the classical Gabor filter model. Using local patches of drifting gratings, we identified heterogeneous orientation tuning in mouse V1 that varied up to 90° across sub-regions of the RF. This heterogeneity correlated with deviations from optimal Gabor filters and was consistent across cortical layers and recording modalities (calcium vs. spikes). In contrast, model-synthesized MEIs for macaque V1 neurons were predominantly Gabor like, consistent with previous studies. These findings suggest that complex spatial feature selectivity emerges earlier in the visual pathway in mice than in primates. This may provide a faster, though less general, method of extracting task-relevant information.
Authors
- Paweł A. Pierzchlewicz (ORCID: https://orcid.org/0000-0002-8247-0836)
- Katrin Franke (ORCID: https://orcid.org/0000-0002-8649-4835)
- Taliah Muhammad (ORCID: https://orcid.org/0000-0002-3242-5391)
- Kelli Restivo (ORCID: https://orcid.org/0000-0001-5754-4883)
- George H. Denfield (ORCID: https://orcid.org/0000-0003-3699-3828)
- Emmanouil Froudarakis (ORCID: https://orcid.org/0000-0002-3249-3845)
- Fabian H. Sinz (ORCID: https://orcid.org/0000-0002-1348-9736)
- Jiakun Fu (ORCID: https://orcid.org/0000-0002-3342-557X)
- Andreas S. Tolias (ORCID: https://orcid.org/0000-0002-4305-6376)
- Kayla Ponder (ORCID: https://orcid.org/0000-0001-7776-1914)
- Maria Diamantaki (ORCID: https://orcid.org/0000-0002-8455-7628)
- Konstantin F. Willeke (ORCID: https://orcid.org/0000-0003-4445-6408)
- Mohammad Bashiri (ORCID: https://orcid.org/0000-0001-7901-0735)
Institutions
- Baylor College of Medicine (US)
- Neurosciences Institute (US)
- University of Göttingen (DE)
- Foundation for Research and Technology Hellas (GR)
- Stanford University (US)
Publication Details
- Journal
- Cell Reports
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1016/j.celrep.2024.114639
- Citations
- 5
- Primary Topic
- Visual perception and processing mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.71
Funders
- National Science Foundation
- Carl-Zeiss-Stiftung
- Kansas NSF EPSCoR
- International Max Planck Research School for Environmental, Cellular and Molecular Microbiology
- European Commission
- Deutsche Forschungsgemeinschaft
- Nihon Superior
- International Max Planck Research School for Advanced Methods in Process and Systems Engineering
- Hellenic Foundation for Research and Innovation
- National Institutes of Health
- Defense Advanced Research Projects Agency
- Advanced Research Projects Agency - Energy
- Advanced Research Projects Agency
- Intelligence Advanced Research Projects Activity
- Interior Business Center
- International Max Planck Research School for Precision Tests of Fundamental Symmetries
- National Eye Institute
- H2020 Fast Track to Innovation
- HORIZON EUROPE Reforming and enhancing the European Research and Innovation system