MicroRNA dysregulation in ataxia telangiectasia
We identified an AT-related miRNA signature in blood cells and fibroblast samples collected from a group of AT patients. We also predicted several dysregulated pathways, primarily related to cancer, immune system control, or inflammatory processes. The findings suggest that miRNAs may provide insights into the pathophysiology and tumorigenesis of AT and have the potential to serve as useful biomarkers in cancer research.
Authors
- Giancarlo Parenti (ORCID: https://orcid.org/0000-0002-6287-5748)
- Giovanna Fabio (ORCID: https://orcid.org/0000-0002-8805-2942)
- Carla Damiano (ORCID: https://orcid.org/0000-0001-8833-6112)
- Elisabetta Toriello
- Antonietta Tarallo
- Francesca Conti (ORCID: https://orcid.org/0000-0002-3665-8926)
- Manuela Ferracin (ORCID: https://orcid.org/0000-0002-1595-6887)
- Maria Carrabba (ORCID: https://orcid.org/0000-0002-0717-9096)
- Elisa Pozzi (ORCID: https://orcid.org/0000-0001-6079-3207)
- Annarosa Soresina
- Claudio Pignata (ORCID: https://orcid.org/0000-0003-1568-9843)
- Lucia Augusta Baselli (ORCID: https://orcid.org/0000-0003-1171-1185)
- Davide Montin (ORCID: https://orcid.org/0000-0001-8953-2182)
- Alfredo Brusco (ORCID: https://orcid.org/0000-0002-8318-7231)
- Roberta Roncarati (ORCID: https://orcid.org/0000-0002-2371-3316)
- Raffaele Badolato (ORCID: https://orcid.org/0000-0001-7375-5410)
- A. De Rosa (ORCID: https://orcid.org/0000-0002-6009-1042)
- Emilia Cirillo (ORCID: https://orcid.org/0000-0002-0605-649X)
- Annamaria Carissimo (ORCID: https://orcid.org/0000-0003-4636-3969)
- Giuliana Giardino (ORCID: https://orcid.org/0000-0002-0621-9527)
- Rosa Maria Dellepiane (ORCID: https://orcid.org/0000-0002-9921-3414)
- Giulio Ferrero (ORCID: https://orcid.org/0000-0002-4580-0680)
- Roberta Romano
- Patrizia Bertolini
Institutions
- Agenzia Regionale per la Protezione Ambientale del Piemonte (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Ospedale Maggiore (IT)
- Istituto per le Applicazioni del Calcolo Mauro Picone (IT)
- Istituto di Genetica Molecolare (IT)
- Ospedale di Parma (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Turin (IT)
- University of Brescia (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-08-19
- DOI
- https://doi.org/10.3389/fimmu.2024.1444130
- Citations
- 3
- Primary Topic
- DNA Repair Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- European Commission
- Ministero della Salute