Antiviral activity of bovine type III interferon against bovine viral diarrhea virus is greatly reduced in bovine turbinate cells due to limited expression of IFN lambda receptor 1 (IL-28Rα)

Our results demonstrate that the sensitivity of cells to bovIFN-λ3 depends not only on the quality but also of the quantity of the IL-28Rα subunit of the heterodimeric receptor. A reduction in IL-28Rα transcript expression was detected in BTu as compared to MDBK cells, despite the absence of spliced variants or SNPs. The establishment of bovIFN-λ3 induced anti-BVDV activity in BTu cells transfected with an IL-28Rα plasmid suggests that the level of expression of this receptor subunit is crucial for the specific antiviral activity of type III IFN in these cells.

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Publication Details

Journal
Frontiers in Immunology
Published
2024-08-19
DOI
https://doi.org/10.3389/fimmu.2024.1441908
Citations
2
Primary Topic
Animal Disease Management and Epidemiology
Type
article
Field-Weighted Citation Impact
1.14

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article

Antiviral activity of bovine type III interferon against bovine viral diarrhea virus is greatly reduced in bovine turbinate cells due to limited expression of IFN lambda receptor 1 (IL-28Rα)

Eduardo Casas, Teresa de los Santos, Carly Kanipe, Shollie M. Falkenberg et al.
2 citations
Frontiers in Immunology
Animal Disease Management and Epidemiology
1.14
article

Antiviral activity of bovine type III interferon against bovine viral diarrhea virus is greatly reduced in bovine turbinate cells due to limited expression of IFN lambda receptor 1 (IL-28Rα)

Eduardo Casas, Teresa de los Santos, Carly Kanipe, Shollie M. Falkenberg, Sarah E. Attreed, Harish Menghwar, David J. Holthausen, Hao Ma, Rohana P. Dassanayake, Randy E. Sacco, Monica Rodriguez-Calzada, Gisselle N. Medina, Kathryn A. Bickel, Fayna Diaz-San Segunda
article en
2 citations

Abstract

Our results demonstrate that the sensitivity of cells to bovIFN-λ3 depends not only on the quality but also of the quantity of the IL-28Rα subunit of the heterodimeric receptor. A reduction in IL-28Rα transcript expression was detected in BTu as compared to MDBK cells, despite the absence of spliced variants or SNPs. The establishment of bovIFN-λ3 induced anti-BVDV activity in BTu cells transfected with an IL-28Rα plasmid suggests that the level of expression of this receptor subunit is crucial for the specific antiviral activity of type III IFN in these cells.

Frontiers in ImmunologyVol. 15
Oak Ridge Associated Universities (US), Agricultural Research Service (US), United States Department of Agriculture (US), Center for Grain and Animal Health Research (US), Plum Island Animal Disease Center (US), National Animal Disease Center (US), Oak Ridge Institute for Science and Education, Auburn University (US)
U.S. Department of Agriculture, Iowa State University, Agricultural Research Service
Good health and well-being
Openalex Percentile: Top 21%
Animal Disease Management and Epidemiology
1.14
DOIOpen Access PDFOpenAlex
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