Prevalence of alternative lengthening of telomeres in pediatric sarcomas determined by the telomeric DNA C-circle assay
Utilizing the ALT-specific CCA we observed ALT in 0% of EFS, 2.7% of RMS, and 71% of OS. These data are comparable to prior studies in EFS and OS using less specific ALT markers. The CCA can provide a robust and sensitive means of identifying ALT in sarcomas and has potential as a companion diagnostic for ALT targeted therapeutics.
Authors
- Frederic G. Barr (ORCID: https://orcid.org/0000-0002-1051-7447)
- Balakrishna Koneru (ORCID: https://orcid.org/0000-0002-2163-7049)
- Trevor A. Burrow (ORCID: https://orcid.org/0000-0001-6838-837X)
- C. Patrick Reynolds (ORCID: https://orcid.org/0000-0002-2827-8536)
- Wenyue Sun (ORCID: https://orcid.org/0000-0003-1673-0895)
- Shawn J. Macha
- Timothy J. Triche
Institutions
- University of Southern California (US)
- Texas Tech University (US)
- Children's Hospital of Los Angeles (US)
- National Cancer Institute (US)
- Texas Tech University Health Sciences Center (US)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2024-08-19
- DOI
- https://doi.org/10.3389/fonc.2024.1399442
- Citations
- 6
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 1.96
Funders
- Cancer Prevention and Research Institute of Texas
- National Institutes of Health
- National Cancer Institute