Clinical practice guidelines for the treatment of Ewing sarcoma (Spanish Sarcoma Research Group-GEIS)
Ewing sarcoma is a small round-cell sarcoma characterized by gene fusion involving EWSR1 (or another TET family protein like FUS) and an ETS family transcription factor. The estimated incidence of this rare bone tumor, which occurs most frequently in adolescents and young adults, is 0.3 per 100,000/year. Although only 25% of patients with Ewing sarcoma are diagnosed with metastatic disease, historical series show that this is a systemic disease. Patient management requires multimodal therapies-including intensive chemotherapy-in addition to local treatments (surgery and/or radiotherapy). In the recurrent/refractory disease setting, different approaches involving systemic treatments and local therapies are also recommended as well as patient inclusion in clinical trials whenever possible. Because of the complexity of Ewing sarcoma diagnosis and treatment, it should be carried out in specialized centers and treatment plans should be designed upfront by a multidisciplinary tumor board. These guidelines provide recommendations for diagnosis, staging, and multimodal treatment of Ewing sarcoma.
Authors
- Ana Sebio (ORCID: https://orcid.org/0000-0003-3333-2370)
- Daniel Bernabéu (ORCID: https://orcid.org/0000-0003-0828-9104)
- Javier Martín‐Broto (ORCID: https://orcid.org/0000-0001-7350-6916)
- Martina Giuppi
- C. Valverde Morales
- Enrique de Álava (ORCID: https://orcid.org/0000-0001-8400-046X)
- J. Orcajo Rincón (ORCID: https://orcid.org/0000-0003-4843-5786)
- Antonio López–Pousa (ORCID: https://orcid.org/0000-0003-1066-3951)
- Cristina Mata Fernández (ORCID: https://orcid.org/0000-0001-9922-0078)
- Erica Collado Ballesteros
- David Marcilla Plaza
- Isidro Gracia Alegría (ORCID: https://orcid.org/0000-0002-9743-4184)
- A. Martín Benlloch
Institutions
- Hospital Universitario La Paz (ES)
- Hospital de Sant Pau (ES)
- Hospital General Universitario Gregorio Marañón (ES)
- Hospital Universitari i Politècnic La Fe (ES)
- Centro de Investigación Biomédica en Red (ES)
- Hospital Universitario Doctor Peset (ES)
- Vall d'Hebron Hospital Universitari (ES)
- Hospital Universitario Fundación Jiménez Díaz (ES)
- Hospital Materno-Infantil (ES)
- Instituto de Biomedicina de Sevilla (ES)
- Hospital Universitario Virgen del Rocío (ES)
- Universidad Autónoma de Madrid (ES)
- Universidad de Sevilla (ES)
Publication Details
- Journal
- Clinical & Translational Oncology
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1007/s12094-024-03602-5
- Citations
- 12
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.03