Genetically predicted lipoprotein(a) associates with coronary artery plaque severity independent of low-density lipoprotein cholesterol
Genetically predicted Lp(a) is positively associated with coronary plaque severity independent of LDL-C, consistent with Lp(a) promoting atherogenesis. However, the effects of Lp(a) may be greater for progression of plaque to obstructive disease than for the initial development of non-obstructive plaque. A limitation of this study is that Lp(a) was estimated using genetic markers and could not be directly assayed nor could apo(a) isoform size.
Authors
- Peter W.F. Wilson (ORCID: https://orcid.org/0000-0002-5653-7056)
- Sunil K. Ahuja (ORCID: https://orcid.org/0000-0002-6001-6181)
- Themistocles L. Assimes (ORCID: https://orcid.org/0000-0003-2349-0009)
- Lori Churby
- Luis E. Selva (ORCID: https://orcid.org/0000-0002-3098-3832)
- Michael E. Matheny (ORCID: https://orcid.org/0000-0003-3217-4147)
- F. A. Gesek
- Jessica V. Brewer
- Ana Palacio (ORCID: https://orcid.org/0000-0001-7808-6359)
- Maureen Murdoch
- Kristin Mattocks (ORCID: https://orcid.org/0000-0002-6012-3008)
- Samuel M. Aguayo
- Peter S. Liang (ORCID: https://orcid.org/0000-0002-4160-421X)
- Agnes Wallbom
- Blake Thomson (ORCID: https://orcid.org/0000-0002-6433-0338)
- Robin A. Hurley (ORCID: https://orcid.org/0009-0002-1720-9348)
- Disha Sharma (ORCID: https://orcid.org/0000-0001-9486-2709)
- Zuhair K. Ballas (ORCID: https://orcid.org/0000-0001-5569-1230)
- X. Michelle Androulakis (ORCID: https://orcid.org/0000-0002-1833-3474)
- Pran Iruvanti
- Paul N. Meyer
- Sujata Bhushan
- Scott L. DuVall (ORCID: https://orcid.org/0000-0002-4898-3865)
- Jennifer Greco (ORCID: https://orcid.org/0000-0002-4649-1568)
- Scott Kinlay (ORCID: https://orcid.org/0000-0001-7687-9136)
- Samuel Poon (ORCID: https://orcid.org/0000-0003-1284-7906)
- Sumitra Muralidhar (ORCID: https://orcid.org/0000-0001-8417-9068)
- Jack Lichy
- Olaoluwa O. Okusaga (ORCID: https://orcid.org/0000-0002-4263-9086)
- Julie Ann Lynch (ORCID: https://orcid.org/0000-0003-0108-2127)
- Kelly Cho (ORCID: https://orcid.org/0000-0003-1727-7076)
- Jonathan P. Moorman (ORCID: https://orcid.org/0000-0002-6102-6541)
- Jennifer E. Deen
- Shiuh‐Wen Luoh (ORCID: https://orcid.org/0000-0001-8355-5332)
- Jon Klein (ORCID: https://orcid.org/0000-0002-3552-7684)
- Louis J. Dell’Italia (ORCID: https://orcid.org/0000-0001-6654-0665)
- Jeff Whittle (ORCID: https://orcid.org/0000-0002-9544-838X)
- Salvador Gutierrez
- Rose D. L. Huang
- Mark B. Hamner (ORCID: https://orcid.org/0000-0002-0532-8764)
- Richard J. Servatius (ORCID: https://orcid.org/0000-0002-7023-4895)
- Shahpoor Alex Shayan
- Saiju Pyarajan (ORCID: https://orcid.org/0000-0002-9047-3762)
- Emily Potter
- Philip S. Tsao (ORCID: https://orcid.org/0000-0001-7274-9318)
- Brady M. Stephens
- Elizabeth R. Hauser (ORCID: https://orcid.org/0000-0003-0367-9189)
- Suthat Liangpunsakul (ORCID: https://orcid.org/0000-0002-6504-8123)
- John B. Harley (ORCID: https://orcid.org/0000-0002-8463-1939)
- Todd Gress
- Neeraj Tandon (ORCID: https://orcid.org/0000-0001-9285-5409)
- Edward J. Boyko (ORCID: https://orcid.org/0000-0002-3695-192X)
- Amy M. Kilbourne (ORCID: https://orcid.org/0000-0001-5815-6401)
- Elisabeth Mates (ORCID: https://orcid.org/0000-0002-9267-1869)
- Patrick J. Strollo
- Michael Rauchman (ORCID: https://orcid.org/0000-0002-4820-3689)
- Kimberly Hammer
- Gerardo Villareal
- L. Christine Faulk (ORCID: https://orcid.org/0000-0002-9355-4525)
- Jean C. Beckham (ORCID: https://orcid.org/0000-0001-8746-8949)
- Darshana Jhala (ORCID: https://orcid.org/0000-0002-4940-4431)
- Henry R. Kranzler (ORCID: https://orcid.org/0000-0002-1018-0450)
- Jennifer Moser (ORCID: https://orcid.org/0000-0002-3642-1531)
- Timothy R. Morgan (ORCID: https://orcid.org/0000-0003-1328-0307)
- Stacey B. Whitbourne (ORCID: https://orcid.org/0000-0002-3472-3464)
- Mary T. Brophy (ORCID: https://orcid.org/0000-0003-2314-4368)
- Michael G. Levin (ORCID: https://orcid.org/0000-0002-9937-9932)
- Samir Gupta (ORCID: https://orcid.org/0000-0003-2656-3912)
- Daryl Fujii (ORCID: https://orcid.org/0000-0001-7887-3352)
- Shoa L. Clarke (ORCID: https://orcid.org/0000-0002-6592-1172)
- Mary A. Whooley (ORCID: https://orcid.org/0000-0002-5943-0078)
- David Cohen (ORCID: https://orcid.org/0000-0003-0935-051X)
- Austin T. Hilliard (ORCID: https://orcid.org/0000-0002-1289-4377)
- Joseph Fayad
- Saib Gappy
- Peruvemba Sriram (ORCID: https://orcid.org/0000-0002-6103-3573)
- Kathrina Alexander
- Frank J. Jacono
- Satish Sharma
- Prakash Balasubramanian
- James E. Norton (ORCID: https://orcid.org/0009-0003-3430-2568)
- J. Michael Gaziano
- Michael Godschalk
- River Smith (ORCID: https://orcid.org/0000-0002-0071-9715)
- Michael Landry
- Stephen Mastorides
- Allison E. Williams
- Kris Ann Oursler
- Shing Shing Yeh
- Junzhe Xu
- John M. Wells
- Dave Oslin
- Ronnie Marrache
- Jessica Walsh
- Charles S. Mahan
- Sumitra Muralidha
Institutions
- VA Palo Alto Health Care System (US)
- VA Boston Healthcare System (US)
- VA Salt Lake City Healthcare System (US)
- Philadelphia VA Medical Center (US)
- Stanford Medicine (US)
- University of Pennsylvania (US)
- Stanford University (US)
Publication Details
- Journal
- European Journal of Preventive Cardiology
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1093/eurjpc/zwae271
- Citations
- 14
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 8.02
Funders
- U.S. Department of Veterans Affairs
- AstraZeneca
- Office of Research and Development
- Alnylam Pharmaceuticals
- Celgene
- Georgia Clinical and Translational Science Alliance
- Astellas Pharma
- National Institutes of Health
- Janssen Pharmaceuticals