Trauma induced coagulopathy is limited to only one out of four shock induced endotheliopathy (SHINE) phenotypes among moderate-severely injured trauma patients: an exploratory analysis
Hierarchical clustering identified four SHINE phenotype in a cohort of trauma patients. Trauma induced coagulopathy was confined to only one of the SHINE phenotypes, encompassing 22% of the total cohort. This phenotype was characterized by severe hypocoagulability and hyperfibrinolysis, which translated to significantly higher transfusion requirements and higher mortality compared to the other SHINE phenotypes with similar injury severity, warranting further investigation.
Authors
- Marc Maegele (ORCID: https://orcid.org/0000-0002-0634-4723)
- Pär I. Johansson (ORCID: https://orcid.org/0000-0001-9778-5964)
- Simon Stanworth (ORCID: https://orcid.org/0000-0002-7414-4950)
- Nicola Curry (ORCID: https://orcid.org/0000-0002-3849-0688)
- Martin Vigstedt (ORCID: https://orcid.org/0000-0003-0896-1204)
- Jakob Stensballe (ORCID: https://orcid.org/0000-0002-2351-9273)
- Ross Davenport (ORCID: https://orcid.org/0000-0002-8593-6582)
- H Henriksen (ORCID: https://orcid.org/0000-0003-1323-9718)
- Karim Brohi (ORCID: https://orcid.org/0000-0003-0643-8866)
- Christine Gaarder (ORCID: https://orcid.org/0000-0002-9485-1783)
- Nicole P. Juffermans (ORCID: https://orcid.org/0000-0002-3039-6574)
Institutions
- University of Copenhagen (DK)
- Oslo University Hospital (NO)
- NHS Blood and Transplant (GB)
- Witten/Herdecke University (DE)
- Queen Mary University of London (GB)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- John Radcliffe Hospital (GB)
- University of Oxford (GB)
- Oxford University Hospitals NHS Trust (GB)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Scandinavian Journal of Trauma Resuscitation and Emergency Medicine
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1186/s13049-024-01236-8
- Citations
- 8
- Primary Topic
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 3.37
Funders
- Københavns Universitet
- Medical Research Council
- FP7 Health