Ac-HSP20 regulates autophagy and promotes the encystation of Acanthamoeba castellanii by inhibiting the PI3K/AKT/mTOR signaling pathway
The results demonstrated that autophagy is positively correlated with the encystation of A. castellanii, and Ac-HSP20 regulates autophagy to maintain the homeostasis of A. castellanii by inhibiting the PI3K /AKT /mTOR signaling pathway, thus promoting the maturation and stability of encystation.
Authors
- Wenyu Zheng
- Xianmin Feng (ORCID: https://orcid.org/0000-0002-5079-350X)
- Siyao Guo (ORCID: https://orcid.org/0000-0002-8402-1866)
- Meiyu Zheng (ORCID: https://orcid.org/0000-0001-6810-1746)
- Dingrui Guo
- Wan Xi
- Di Liu (ORCID: https://orcid.org/0000-0003-3693-2726)
Institutions
- Jilin City Central Hospital (CN)
- Jilin Medical University (CN)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1186/s13071-024-06436-w
- Citations
- 2
- Primary Topic
- Legionella and Acanthamoeba research
- Type
- article
- Field-Weighted Citation Impact
- 1.24
Funders
- National Natural Science Foundation of China
- National College Students Innovation and Entrepreneurship Training Program