Safflower Alleviates Pulmonary Arterial Hypertension by Inactivating NLRP3: A Combined Approach of Network Pharmacology and Experimental Verification
Our findings suggest that safflower mitigates PAH primarily by inhibiting NLRP3 inflammasome activation. This provides novel insights into the potential use of safflower as an alternative therapeutic approach for PAH.
Authors
- Chuhui Ru
- A. Ling Chen (ORCID: https://orcid.org/0009-0003-9971-9102)
- Shibiao Ding (ORCID: https://orcid.org/0000-0003-4945-7434)
- Fei He (ORCID: https://orcid.org/0009-0000-5032-7333)
- Luning Yan
- Jinyu Cui
Institutions
- Zhejiang Hospital (CN)
- Hangzhou Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- The Clinical Respiratory Journal
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1111/crj.13826
- Citations
- 6
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.51