Is deep brain imaging on the brink of transformation with a bioluminescence molecule?
Cephalofurimazine (CFz), when paired with Antares luciferase, shows superior blood-brain barrier permeability and enhanced imaging depth and clarity for deep brain imaging. This bioluminescence provides a less invasive method for real-time monitoring of deep brain activity, with the potential to advance targeted therapies and deepen our understanding of brain functions. Further molecular engineering and localized delivery can reduce the potential toxicity of CFz and enhance its efficacy for clinical deep brain imaging.
Authors
- Shumao Xu
- Farid Manshaii (ORCID: https://orcid.org/0009-0007-4580-9259)
- Jun Chen (ORCID: https://orcid.org/0000-0002-3439-0495)
Institutions
- University of California, Los Angeles (US)
Publication Details
- Journal
- BMEMat
- Published
- 2024-08-16
- DOI
- https://doi.org/10.1002/bmm2.12115
- Citations
- 5
- Primary Topic
- bioluminescence and chemiluminescence research
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Brain and Behavior Research Foundation
- American Heart Association
- National Institutes of Health
- University of California, Los Angeles
- Office of Naval Research
- Clinical and Translational Science Institute, University of California, Los Angeles