Alginate‐Based Emulsion Micro‐Spheres as 5‐Fluorouracil Carriers

Abstract The present study aims to investigate the potential of alginate microspheres, formulated by emulsion technique, as a drug delivery system for 5‐Fluorouracil. Three different concentrations of alginate, namely 1%, 2%, and 3%, are used in the synthesis. The spheres are characterized in terms of their size, morphology, process yield, and loading efficiency. Based on these parameters, the model formulated from 1% alginate is chosen and loaded with different concentrations of 5‐Fluorouracil achieving polymer to drug mass ratios 2:1, 4:1, and 6:1. The release process of the drug is completed in 3 h, showing burst effect for all models. The faster release from Model 2:1 is associated with the biggest drug amount and its accumulation on the periphery of the spheres.